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SRP5042

Sigma-Aldrich

JNK2, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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Synonym(s):
JNK-55, JNK2α, JNK2β, JNK2A, JNK2B, MAPK9, PRKM9, SAPK, p54a, p54aSAPK
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

11-15 nmol/min·mg

mol wt

~70 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MAPK9(5601)

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This Item
E1283SAB1406300E7407
JNK2, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

SRP5042

JNK2, active, GST tagged human

Sigma-Aldrich

E1283

ERK2, active, GST tagged human

Sigma-Aldrich

E7407

ERK1, active, untagged human

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

-

assay

≥70% (SDS-PAGE)

mol wt

~70 kDa

mol wt

~68 kDa

mol wt

antigen ~48.3 kDa

mol wt

~44 kDa

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−70°C

Biochem/physiol Actions

JNK2 is a member of the JNK family that acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK2 targets specific transcription factors, and mediates immediate-early gene expression in response to various cell stimuli. Both UV radiation and the proinflammatory cytokine TNFα can induce JNK2. JNK2 play a main role in the regulation of regional specific apoptosis during early brain development and providing protection against autoimmune diabetes.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Anja Jaeschke et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(19), 6931-6935 (2005-05-04)
The c-Jun NH(2)-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that JNK2 may play an important role in type
C Y Kuan et al.
Neuron, 22(4), 667-676 (1999-05-07)
The c-Jun NH2-terminal kinase (Jnk) family is implicated in apoptosis, but its function in brain development is unclear. Here, we address this issue using mutant mice lacking different members of the family (Jnk1, Jnk2, and Jnk3). Mice deficient in Jnk1

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