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T1450

Sigma-Aldrich

Anti-γ-Tubulin (LL-17) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-γ-Tubulin (LL-17)
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

Caenorhabditis elegans

technique(s)

western blot: 0.75-1.5 μg/mL using whole extract of C. elegans.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

Caenorhabditis elegans ... Tbg-1(176361)

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T3195T3559T6557
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

ascites fluid

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

Caenorhabditis elegans ... Tbg-1(176361)

Gene Information

human ... TUBG1(7283), TUBG2(27175)

Gene Information

human ... TUBG1(7283), TUBG2(27175)

Gene Information

human ... TUBG1(7283)
mouse ... Tubg1(103733)
rat ... Tubg1(252921)

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General description

γ-Tubulin is a widely expressed and highly conserved protein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells. It is a member of the tubulin superfamily of proteins, which includes α and β tubulin and the newly discovered centrosomal-associated proteins, δ and ε tubulin. γ-Tubulin abundance is less than 1% of the level of either α or β tubulin.

Immunogen

synthetic peptide corresponding to the C-terminus of C. elegans γ-tubulin (amino acids 428-444) with N-terminal added cysteine, conjugated to KLH. This sequence is highly specific for C. elegans γ-tubulin, and not found in γ-tubulin sequences of other species or other members of the tubulin family such as α-, β-, δ-, and ε-tubulins.

Application

Anti-γ-Tubulin (LL-17) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

γ-Tubulin has an essential role in microtubule nucleation by the centrosomes. γ-Tubulin does not polymerize with α-tubulin/β-tubulin, but instead it is localized to the centrosome and to the cytoplasm. γ-Tubulin is found as part of a large protein complex containing at least five other proteins and has a shape of a ring (γ-tubulin ring complex, γ-TuRC) that is roughly the same diameter as a microtubule. γ-Tubulin binds the microtubule minus ends and is responsible for mediating the link between microtubules and the centrosome.

Target description

γTubulin (LL-17) is a widely expressed and highly conservedprotein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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An abundance of tubulins
Oakley BR
Trends in Cell Biology, 10(12), 537-542 (2000)
Nikhita Anand et al.
Neurobiology of disease, 139, 104786-104786 (2020-02-08)
Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neurodegeneration as a potential
δ-tubulin and ?-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function
Chang P, et al.
Nature Cell Biology, 2(1), 30-30 (2000)
Charlotte P Choi et al.
eLife, 10 (2021-02-16)
Piwi-interacting RNAs (piRNAs) play essential roles in silencing repetitive elements to promote fertility in metazoans. Studies in worms, flies, and mammals reveal that piRNAs are expressed in a sex-specific manner. However, the mechanisms underlying this sex-specific regulation are unknown. Here

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