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U3385

Sigma-Aldrich

UA62784

≥98% (HPLC)

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Synonym(s):
4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
Empirical Formula (Hill Notation):
C23H15NO3
CAS Number:
Molecular Weight:
353.37
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >2 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34

InChI

1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3

Inchi Key

SVICLWPFAQYZLX-UHFFFAOYSA-N

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1 of 4

This Item
SML1827SML2225SML1464
UA62784 ≥98% (HPLC)

Sigma-Aldrich

U3385

UA62784

CCF642 ≥98% (HPLC)

Sigma-Aldrich

SML1827

CCF642

RO5263397 ≥98% (HPLC)

Sigma-Aldrich

SML2225

RO5263397

SMBA1 ≥98% (HPLC)

Sigma-Aldrich

SML1464

SMBA1

form

powder

form

powder

form

powder

form

powder

color

yellow

color

yellow to orange

color

white to beige

color

white to beige

solubility

DMSO: >2 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

Biochem/physiol Actions

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

Preparation Note

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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25G
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1000309185

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Sergey Tcherniuk et al.
Chemistry & biology, 18(5), 631-641 (2011-05-26)
A recent screen for compounds that selectively targeted pancreatic cancer cells isolated UA62784. We found that UA62784 inhibits microtubule polymerization in vitro. UA62784 interacts with tubulin dimers ten times more potently than colchicine, vinblastine, or nocodazole. Competition experiments revealed that UA62784
Julia Würtemberger et al.
PloS one, 15(9), e0238572-e0238572 (2020-09-09)
Functional genomic screening of KRAS-driven mouse sarcomas was previously employed to identify proliferation-relevant genes. Genes identified included Ubiquitin-conjugating enzyme E2 (Ube2c), Centromere Protein E (Cenpe), Hyaluronan Synthase 2 (Has2), and CAMP Responsive Element Binding Protein 3 Like 2 (Creb3l2). This

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