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V1130

Sigma-Aldrich

Vancomycin hydrochloride from Streptomyces orientalis

BioReagent, suitable for plant cell culture

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About This Item

Empirical Formula (Hill Notation):
C66H75Cl2N9O24 · HCl
CAS Number:
1404-93-9
Molecular Weight:
1485.71
Beilstein/REAXYS Number:
3704657
UNSPSC Code:
10171502
NACRES:
NA.72
Pricing and availability is not currently available.

biological source

Streptomyces orientalis

Quality Level

200

product line

BioReagent

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

concentration

≥900 μg/mg (as vancomycin base)

technique(s)

cell culture | plant: suitable

color

, off-white to brown or White to orange-brown

solubility

H2O: 50 mg/mL, clear, colorless to dark yellow (and Very Faint Orange to Faint Orange)

antibiotic activity spectrum

Gram-positive bacteria

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General description

Chemical structure: glycopeptide
Vancomycin is a heptapeptide.[1]

Application

Vancomycin hydrochloride from Streptomyces orientalis has been used as:
  • an antibiotic in screening: minimal inhibitory concentrations (MICs) Streptomyces coelicolor[2]
  • in treating Leishmania infected sand flies[3]
  • in combined antibiotic treatment in asthma induced mice[4]

Biochem/physiol Actions

Mode of action: Inhibits incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides.

Antimicrobial Spectrum: Active against Gram-positive bacteria
Vancomycin is used for treating methicillin-resistant Staphylococcus aureus (MRSA) infections[1] and shunt-associated Staphylococcal ventriculitis.[5] It may lead to hypersensitivity reactions like anaphylaxis and red man syndrome.[6] Vanomycin is also used to treat thrombocytopenia[7] and induces drug reaction with eosinophilia and systemic symptoms (DRESS) on usage.[7]

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000437699
0000437699
0000438495
0000437691
0000437691

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T Asano et al.
Phytopathology, 89(4), 314-319 (2008-10-24)
ABSTRACT Resting spores of Plasmodiophora brassicae were surface-disinfested by treatment with 2% chloramine-T for 20 min and then with an antibiotic solution (1,000 ppm of colistin sulfate, 1,000 ppm of vancomycin hydrochloride, and 6,000 ppm of cefotaxime sodium) for 1
Red man syndrome
Sivagnanam S and Deleu D
Critical Care, 7(2), 119-119 (2002)
Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma
Adami AJ, et al.
Pediatric Research, 84(3), 426-426 (2018)
Vancomycin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Masquerading as Elusive Sepsis
Roy S, et al.
Case reports in immunology, 2019, 119-119 (2019)
Optimization of fermentation conditions for production of glycopeptide antibiotic vancomycin by Amycolatopsis orientalis
Padma PN, et al.
Applied Biochemistry and Biotechnology, 102(1-6), 395-405 (2002)
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