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WH0001269M1

Sigma-Aldrich

Monoclonal Anti-CNR2 antibody produced in mouse

clone 3C7, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-CB2, Anti-CX5, Anti-cannabinoid receptor 2 (macrophage)
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3C7, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CNR2(1269)

General description

Cannabinoid receptor 2 (CNR2) is encoded by the gene mapped to human chromosome 1p36.11. The encoded protein belongs to a novel cadherin-related multigene family. Members of this family contain six cadherin repeats and conserved DXNDNXPXF and DXD motifs with constitute putative calcium-binding sequences.
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. (provided by RefSeq)

Immunogen

CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
RSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

Application

Monoclonal Anti-CNR2 antibody produced in mouse has been used in western blot analysis.

Biochem/physiol Actions

Cannabinoid receptor 2 (CNR2) plays a crucial role in mediating anti-inflammatory and anti-atherosclerotic effects in vivo. It is also involved in cancer, bone metabolism and pain perception. CNR2 might be implicated in selective cell–cell interaction. Mutations in the gene has been associated with trochanter and hip bone mineral density (BMD).

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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