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73035AST

Supelco

Astec® CHIRALDEX G-TA Capillary GC Column

L × I.D. 50 m × 0.25 mm, df 0.12 μm

Synonym(s):

GC column, chiral, gamma-dextran

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About This Item

UNSPSC Code:
41115710
NACRES:
SB.54

material

fused silica

description

GC capillary column

packaging

pkg of 1 ea

parameter

-10-180 °C temperature (isothermal or programmed)

Beta value

500

df

0.12 μm

technique(s)

gas chromatography (GC): suitable

L × I.D.

50 m × 0.25 mm

matrix active group

non-bonded; 2,6-di-O-pentyl-3-trifluoroacetyl derivative of γ-cyclodextrin phase

application(s)

agriculture
chemicals and industrial polymers
cleaning products
clinical
cosmetics
environmental
flavors and fragrances
food and beverages
forensics and toxicology
life science and biopharma
personal care
pharmaceutical (small molecule)

column type

capillary chiral

separation technique

chiral

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General description

Astec® CHIRALDEX G-TA is the first choice in the Group 1 CSPs (Surface Interactions, Complex Derivatives). This phase has been shown to be the most broadly-selective phase for the pharmaceutical industry, especially for the analysis of chiral intermediates and drug studies in various stages of clinical trials. Separations occur without the inclusion mechanism and are typically faster and more efficient than most chiral stationary phases. G-TA has also been used to separate parent drug enantiomers and their metabolites. G-TA has its highest selectivity for oxygen-containing analytes like alcohols, diols and polyols as the free alcohol and as an acyl derivative; amines as acyl derivatives; amino alcohols, halogens (Cl>Br>F), amino acids, hydroxy acids, lactones, furans and pyrans. It is also highly selective for halogenated compounds.

Application


  • Enantioselective gas chromatographic analysis of aqueous samples by on-line derivatisation. Application to enzymatic reactions.: This study explores the use of the Astec CHIRALDEX G-TA Capillary GC Column for enantioselective gas chromatographic analysis. The method involves on-line derivatization, enabling the analysis of aqueous samples and applying this technique to enzymatic reactions. This innovative approach highlights the column′s capability in achieving high selectivity and sensitivity for chiral compounds in complex matrices (Mommers et al., 2008).

Chem/Phys Resistance

Temp. Limits:
  • -10 °C to 180 °C isothermal and programmed

Other Notes

We offer a variety of chromatography accessories including analytical syringes

Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIRALDEX is a trademark of Sigma-Aldrich Co. LLC

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Isolation of racemic 2,4-pentanediol and 2,5-hexanediol from commercial mixtures of racemic and meso isomers by way of cyclic sulfites.
Caron, Gaetan; Kazlauskas, R.J.
Tetrahedron Asymmetry, 5 (4), 657-664 (1994)
The synthesis of enantioenriched a-hydroxy esters
Gu, Xin, et al.
Tetrahedron Asymmetry, 25 (24), 1573-1580 (2014)
The asymmetric hydrogenation of 2-phenethylacrylic acid as the key step for the enantioselective synthesis of Citralis Nitrile?
Scrivanti, Alberto, et al.
Tetrahedron Letters, 47 (52), 9261-9265 (2006)
Organocatalysis using protonated 1,2-diamino-1,2-diphenylethane for asymmetric Diels?Alder reaction
Hoon Kim, Kyoung, et al.
Tetrahedron Letters, 46 (36), 5991-5994 (2005)
Asymmetric conjugate addition to alkylidene malonates
Alexakis, Alexandre; Benhaim, Cyril;
Tetrahedron Asymmetry, 12 (8), 1151-1157 (2001)

Articles

Chromatographic enantiomeric separation of amino acids, like proline, is described for chiral GC analysis after derivatization.

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