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1265515

USP

Ethylene glycol

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
Ethylene glycol, 1,2-Ethanediol
Linear Formula:
HOCH2CH2OH
CAS Number:
Molecular Weight:
62.07
Beilstein/REAXYS Number:
505945
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

vapor density

2.1 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)

autoignition temp.

752 °F

expl. lim.

15.3 %

manufacturer/tradename

USP

refractive index

n20/D 1.431 (lit.)

bp

195-198 °C

mp

−13 °C (lit.)

density

1.113 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OCCO

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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1 of 4

This Item
PHR1046859781.09621
Ethylene glycol United States Pharmacopeia (USP) Reference Standard

1265515

Ethylene glycol

Ethylene glycol Pharmaceutical Secondary Standard; Certified Reference Material

PHR1046

Ethylene glycol

Ethylene glycol analytical standard

85978

Ethylene glycol

Ethylene glycol for analysis EMSURE® Reag. Ph Eur,Reag. USP

1.09621

Ethylene glycol

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

format

neat

format

neat

format

neat

format

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

environmental

application(s)

-

vapor density

2.1 (vs air)

vapor density

2.1 (vs air)

vapor density

2.1 (vs air)

vapor density

-

vapor pressure

0.08 mmHg ( 20 °C)

vapor pressure

0.08 mmHg ( 20 °C)

vapor pressure

0.08 mmHg ( 20 °C)

vapor pressure

0.053 hPa ( 20 °C)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This USP reference standard is intended for use in specified quality tests and assays as specified in the USP compendia.
It is also used in the preparation of standard solution for determining the concentration of residual ethylene glycol as an impurity in ethoxylated products by gas chromatography (GC) coupled to a flame ionization detector (FID), in accordance with the United States Pharmacopeia (USP) chapter 469 “Ethylene Glycol, Diethylene Glycol, and Triethylene Glycol in Ethoxylated Products”.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Related product

pictograms

Exclamation markHealth hazard

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - STOT RE 2 Oral

target_organs

Kidney

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

239.0 °F - open cup

flash_point_c

115 °C - open cup


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USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 6164-6164 (2013)
Ethylene Glycol, Diethylene Glycol, and Triethylene Glycol in Ethoxylated Products
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(4), 6733-6733 (2014)
Frank F J Simonis et al.
Magnetic resonance in medicine, 73(3), 1184-1189 (2014-03-26)
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Robert Hess et al.
Archives of toxicology, 78(12), 671-680 (2004-09-17)
Upon ingestion ethylene glycol (EG, monoethylene glycol) is rapidly absorbed from the gastrointestinal tract, and depending on the severity of exposure signs of toxicity may progress through three stages. Neurological effects characterize the first step consisting of central nervous depression
Eurwin Suryana et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 37, 69-75 (2014-07-11)
Myelination is an essential process in human development that is carried out by oligodendrocytes in the central nervous system. Hypoxic-ischaemic (HI) brain injury can disrupt myelination by causing oxidative stress, inflammation and excitotoxicity, resulting in the loss of myelin as

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