1292347

Glimepiride Related Compound D

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[3-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide, 1-[[m-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea
• Empirical Formula (Hill Notation): C₂₄H₃₄N₄O₅S
• CAS Number: 791104-62-6
• Molecular Weight: 490.62
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: glimepiride
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• InChI: 1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-13-12-18-6-5-7-20(14-18)34(32,33)27-23(30)26-19-10-8-16(2)9-11-19/h5-7,14,16,19H,4,8-13,15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-
• InChI key: XBXROPCBZLGQMA-RUCARUNLSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

• Glucosamine substituted sulfonylureas: Research into glucosamine substituted sulfonylureas, including analogues of Glimepiride, highlights their potential in modulating the IRS-PI3K-PKC-AKT-GLUT4 insulin signaling pathway. This suggests new therapeutic avenues for diabetes management, specifically enhancing insulin sensitivity and glucose uptake (Suaifan et al., 2024).


• Insulin sensitivity and β-cell function study: Studies involving Glimepiride have examined its impact on insulin sensitivity and β-cell function over time, comparing it to other therapeutic agents. This research is crucial for understanding the differential effects of diabetes treatments, including those related to Glimepiride′s metabolites and impurities (Utzschneider et al., 2024).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable