Tangential Flow Filtration Holders & Systems
Benefiting from our leading bioprocess knowledge and engineering expertise in tangential flow filtration (TFF), we have developed multi-use, single-use, and process development systems incorporating many unique, innovative, and intelligent features. Our systems are designed to meet the success criteria for purification by tangential filtration, including low hold-up volume, maximum volume concentration, and optimal product recovery for enhanced process performance.
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PROCESS-SCALE SINGLE-USE TFF SYSTEMS
Our Mobius® FlexReady Solution for TFF and Mobius® TFF 80 system provide a combination of single-use Flexware® assemblies and hardware specifically designed for efficient concentration and diafiltration of proteins. With installable filter area ranging from 0.5 to 20 m2, flow range from 2 to 80 L/min, and tank size from 50 to 500 L, our range of single-use TFF systems can adapt to your process needs from pre-clinical to manufacturing scale. Closed mode of operation is possible with specifically designed flowpath and equipment, allowing to reduce contamination risk and protect operators while increasing flexibility and efficiency. This family of equipment features:
- Clinical to large scale capabilities, with no compromise on quality
- Design for optimized yield and product recovery
- Multi-product and multi-processing modes
- Full automation, user friendly
Process-scale multi-use TFF systems
The fully automated Cogent® Process-Scale TFF System is designed to separate and purify monoclonal antibodies, vaccines, plasma, and therapeutic proteins. It is ideally suited for both pilot and production scale applications, thereby supporting rapid scale-up from small- to large-scale operations. Other key system features include:
- Modular options for the system configuration that best matches process requirements, while minimizing upfront investment
- Full process automation
- Optimized design and component integration of NovAseptic® valves and TFF cassette holders for lowest minimum working volume and maximum product recovery
- Processes operated in fed-batch, concentration, total recycle, or single-pass mode.
PROCESS DEVELOPMENT TFF SYSTEMS
Our family of Cogent® Lab systems uses similar design, sensing technologies, and accessories as our manufacturing-scale equipment. With a homogeneous design and flow range from 20 to 6000 mL/min, our systems have been specifically created to simplify process development. The Cogent® Lab 150, 800, and 6000 systems are optimized for high product recovery and drainability, ensuring successful small-scale TFF operations.
- One family of TFF systems with harmonized design and linear performance ensures successful and seamless scale-up or scale-down
- User-friendly Bio4C® Control Software offers pre-defined recipe steps, real-time data visualization and export capabilities assuring reliable and reproducible results
- Cogent® Lab systems can be tailored to your specific process with an extensive list of options
- Flexibly operates in UF/DF, microfiltration or SPTFF mode and across a wide range of parameters
Holders for Pellicon® flat sheet devices
Our systems are best suited for use with Pellicon® expendables, either in single-use (Pellicon® Capsule) or multi-use applications (Pellicon® 2 and 3). Holders may be included when purchasing a TFF system; please refer to the appropriate data sheet for details. We provide self-standing holders for filtration area from 88 cm² to 130 m² depending on expendables.
- XX42PMICR0 holder for Pellicon® 3 micro from 88 cm² to 264 cm²
- XX42PMINI holder for Pellicon® 2 and 3 from 0.1 m² to 0.55 m²
- Pellicon® Process scale holders for Pellicon® 2 and 3 from 0.5 m² and above
Options are available to increase the installed surface and run in single-pass mode.
Related Resources
- Perf. Guide: Mobius® TFF 80 System
This guide includes information from a number of applications and case studies that were designed and/or selected to provide a diverse overview of the system performance under a range of expected processing conditions.
- Spare Parts List: Mobius® TFF 80 System
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock. The risk assessment is based on our experience; each customer must perform their individual risk assessment for their process, to check the alignment with our strategy and review the stock requirements accordingly.
- Data Sheet: Mobius® FlexReady Solution for TFF
The Mobius® FlexReady Solution with Smart Flexware® Assemblies is flexible, allowing you to have a single system for tangential flow filtration (TFF) at various scales.
- Performance Guide: Mobius® FlexReady Solution (TF2S) with Smart Flexware® Assemblies for TFF with Closed Enabled Configuration
This Performance Guide is a reference document that provides highlights of key performance aspects of the Mobius® FlexReady Solution with Smart Flexware® Assemblies for Tangential Flow Filtration (TFF) used with a closed-enabled flowpath.
- Spec. Sheet: Mobius® FlexReady Solution with Smart Flexware® Assemblies for TFF
Flexible design options; Unique feed tank design and performance; Smart Flexware® full single-use flow paths; Excellent product recovery and purification; Implement with ease and lower risks; Full process automation with flexible recipes using the Common Control Platform® (CCP®)
- Spare Parts List: Mobius® FlexReady Solution
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock. The risk assessment is based on our experience; each customer must perform their individual risk assessment for their process, to check the alignment with our strategy and review the stock requirements accordingly.
- Data Sheet: Cogent® Process-scale Tangential Flow Filtration System
Fully automated, configurable systems for biopharmaceutical manufacturing and cGMP process scale applications
- Data Sheet: Cogent® Lab Systems
A family of modular and flexible systems for TFF at process development scale
- Spare Parts List - Cogent® Lab Systems
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock.
- Application Note: Running a TFF optimization study with Cogent® Lab Systems and Bio4C® Control Software
This application note describes the recommended methods and techniques for optimizing a tangential flow filtration (TFF) process using a Cogent® Lab system.
- Brochure: Process Development and Drug Manufacturing: Support Services
We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.
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