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  • Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa.

Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa.

Bioorganic & medicinal chemistry letters (2011-01-05)
Van Kiem Phan, Xuan Cuong Nguyen, Xuan Nhiem Nguyen, Kim Thu Vu, Khac Ban Ninh, Van Minh Chau, Huu Tai Bui, Nam Hai Truong, Sang Hyun Lee, Hae Dong Jang, Young Ho Kim
ABSTRACT

By bioactive-guided fractionation of methanol extract of the Ficus microcarpa leaves, one new C-glucosylflavone, ficuflavoside (1), one new megastigmane glycoside, ficumegasoside (8), and twelve known compounds including flavonoids (2-6), phenylpropanoids (7), megastigmanes (9-11) and sterol derivatives (12-14) were isolated. Their chemical structures were elucidated by mass, 1D, and 2D NMR spectroscopies. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity methods. Compounds 1-6 exhibited potent antioxidant activities of 6.6-9.5μM Trolox equivalents at the concentration of 2.0μM. The results indicated 2, 3, and 5 having meaningful reducing capacity of copper (I) ions concentration of 6.1-8.4μM.

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