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  • Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

Proceedings of the National Academy of Sciences of the United States of America (1991-12-15)
D Papahadjopoulos, T M Allen, A Gabizon, E Mayhew, K Matthay, S K Huang, K D Lee, M C Woodle, D D Lasic, C Redemann
ABSTRACT

The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect is substantially greater than that observed previously with conventional liposomes and is associated with a more than 5-fold prolongation of liposome circulation time in blood, a marked decrease in uptake by tissues such as liver and spleen, and a corresponding increased accumulation in implanted tumors. These and other properties described here have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
NanoFabTX-DOTAP Lipid Mix, for synthesis of cationic (DOTAP) liposomes
Sigma-Aldrich
NanoFabTx - PEG Lipid Mix, for synthesis of PEGylated liposomes
Sigma-Aldrich
NanoFabTx- COOH Lipid Mix, for synthesis of carboxyl functionalized liposomes
Sigma-Aldrich
NanoFabTx-DC-Chol Lipid Mix, for synthesis of cationic (DC-cholesterol) liposomes
Sigma-Aldrich
NanoFabTX- NH2 Lipid Mix, for synthesis of amine functionalized liposomes