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  • Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications.

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications.

Artificial cells, nanomedicine, and biotechnology (2017-03-11)
Yunes Panahi, Masoud Farshbaf, Majid Mohammadhosseini, Mozhdeh Mirahadi, Rovshan Khalilov, Siamak Saghfi, Abolfazl Akbarzadeh
ABSTRACT

Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability; accompanied by their nanosize they have potential applications in nanomedicine, cosmetics, and food industry. Nanoliposome technology offers thrilling chances for food technologists in fields including encapsulation and controlled release of food ingredients, also improved bioavailability and stability of sensitive materials. Amid numerous brilliant new drug and gene delivery systems, liposomes provide an advanced technology to carry active molecules to the specific site of action, and now days, various formulations are in clinical use. In this paper, we provide review of the main physicochemical properties of liposomes, current methods of the manufacturing and introduce some of their usage in food nanotechnology as carrier vehicles of nutrients, enzymes, and food antimicrobials and their applications as drug carriers and gene delivery agents in biomedicine.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
NanoFabTX-DOTAP Lipid Mix, for synthesis of cationic (DOTAP) liposomes
Sigma-Aldrich
NanoFabTx - PEG Lipid Mix, for synthesis of PEGylated liposomes
Sigma-Aldrich
NanoFabTx- COOH Lipid Mix, for synthesis of carboxyl functionalized liposomes
Sigma-Aldrich
NanoFabTx-DC-Chol Lipid Mix, for synthesis of cationic (DC-cholesterol) liposomes
Sigma-Aldrich
NanoFabTX- NH2 Lipid Mix, for synthesis of amine functionalized liposomes