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  • Novel insights into Mycobacterium antigen Ag85 biology and implications in countermeasures for M. tuberculosis.

Novel insights into Mycobacterium antigen Ag85 biology and implications in countermeasures for M. tuberculosis.

Critical reviews in eukaryotic gene expression (2012-11-13)
XieMei Tang, Wanyan Deng, Jianping Xie
ABSTRACT

Tuberculosis remains one of the most prevalent and deadly infectious diseases, largely due to the emergence of multidrug-resistant and extensive drug-resistant Mycobacterium tuberculosis, especially the coinfection with HIV. Mycobacterium Ag85 complex (Ag85A, B, and C), with a carboxylesterase consensus sequence and conserved surface catalysis residues, involves in cell wall biosynthesis and the trigger of the host immune response. The physiological function, structures, distributions, and molecular mechanisms of regulations as well as their implications in novel vaccines and diagnostics against tuberculosis are summarized. Special focus is the regulation underlying the Ag85 expression. This will facilitate in-depth understanding of the role of Ag85 and developing better novel measures against M. tuberculosis infection.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Esterase from porcine liver, lyophilized, powder, slightly beige, ≥50 U/mg
Sigma-Aldrich
Esterase from porcine liver, lyophilized powder, ≥15 units/mg solid
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Esterase from rabbit liver, lyophilized powder, ≥30 units/mg protein
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Esterase from porcine liver, ammonium sulfate suspension, ≥150 units/mg protein (biuret)
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Esterase from Bacillus subtilis, recombinant, expressed in E. coli, ≥10 U/mg
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Esterase Isoenzyme 1 porcine liver, recombinant, recombinant, expressed in E. coli, ≥30.0 U/g
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Carboxylesterase 2 human, recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)
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Esterase Pseudomonas fluorescens, recombinant from E. coli, ≥4 U/mg
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Esterase from Bacillus stearothermophilus, ≥0.2 U/mg
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Carboxylesterase 1 isoform b human, recombinant, expressed in baculovirus infected BTI insect cells
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Carboxylesterase 1 isoform c human, recombinant, expressed in baculovirus infected BTI insect cells
Sigma-Aldrich
Esterase from Bacillus stearothermophilus, recombinant, expressed in E. coli, ≥4.0 U/mg