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  • Efficient iron/copper cocatalyzed S-arylations of thiols with aryl halides.

Efficient iron/copper cocatalyzed S-arylations of thiols with aryl halides.

Journal of combinatorial chemistry (2009-03-06)
Xin Ku, He Huang, Hualiang Jiang, Hong Liu
ABSTRACT

A practical and promising protocol was developed for S-arylations of various thiols with different substituted aryl halides. The reactions were readily facilitated to afford desired thioethers under mild conditions in good to excellent yields. The versatility, air-stability, operational simplicity of this method, in addition to the higher yields and shorter reaction time it provides, highlight the potential of using this method in large scale library synthesis involving carbon-heteroatom formation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
N,N,N′,N′-Tetramethylethylenediamine, BioReagent, suitable for electrophoresis, ≥99.0%
Sigma-Aldrich
N,N,N′,N′-Tetramethylethylenediamine, ≥99.5%, purified by redistillation
Sigma-Aldrich
N,N,N′,N′-Tetramethylethylenediamine, ReagentPlus®, 99%
Sigma-Aldrich
N,N,N′,N′-Tetramethylethylenediamine, BioReagent, for molecular biology, ≥99% (GC)