- A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells.
A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells.
Angewandte Chemie (International ed. in English) (2012-11-06)
Jungwoon Lee, Yan Xia, Mi-Young Son, Guanghai Jin, Binna Seol, Min-Jeong Kim, Myung Jin Son, Misol Do, Minho Lee, Dongsup Kim, Kyeong Lee, Yee Sook Cho
PMID23125037
ABSTRACT
Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
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