- [Experimental evaluation of reamberin and cytoflavin effects on the course and outcome of acute burn injury].
[Experimental evaluation of reamberin and cytoflavin effects on the course and outcome of acute burn injury].
Eksperimental'naia i klinicheskaia farmakologiia (2013-06-15)
E V Zinov'ev, Iu V Nesterov, T O Lagvilava
PMID23762989
ABSTRACT
Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of IIIB degree (20% of body surface) against early introduction of antihypoxants reamberin and cytoflavin. It is established that the introduction of antihypoxants reliably prevents the development of typical pathologic processes and hypoxemia, reduces expressiveness of organ dysfunction and extent of mophological changes in internal organs, and increases 1.5 - 2.5 times the survival rate of heavily damaged animals in the acute period of burn injury.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Riboflavin 5′-monophosphate sodium salt hydrate, suitable for electrophoresis, suitable for acrylamide photopolymerization, ≥70%, powder
Riboflavin sodium phosphate, European Pharmacopoeia (EP) Reference Standard
Nicotinamide, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Nicotinamide, BioReagent, suitable for cell culture, suitable for insect cell culture
Supelco
Nicotinamide (Vitamin B3) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®