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Comutagenesis-I: the in vitro metabolism of 2-amino-3-methylpyridine.

Anticancer research (1997-12-31)
T G Altuntas, D Manson, K Zhao, J W Gorrod
ABSTRACT

The metabolism of the comutagen 2-amino-3-methylpyridine has been studied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-methylpyridine-N-oxide, 2-amino-3-hydroxymethylpyridine and 2-amino-5-hydroxy-3-methylpyridine were formed by both rat and rabbit hepatic preparations. No evidence was obtained for the formation of the corresponding 2-hydroxylamine, 2-nitroso, 2-nitro-3-methyl-pyridine or their condensation products i.e. azo, azoxy or hydrazo. The results are discussed in relation to the possible mechanism of action of the substrate.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Amino-3-methylpyridine, 95%