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  • Comutagenesis--V: rapid conversion of 2-hydroxyl-amino-3-methylpyridineto 2-amino-3-methylpyridine by a hepatic S9 preparation.

Comutagenesis--V: rapid conversion of 2-hydroxyl-amino-3-methylpyridineto 2-amino-3-methylpyridine by a hepatic S9 preparation.

European journal of drug metabolism and pharmacokinetics (1998-03-26)
J W Gorrod, T G Altuntas
ABSTRACT

The in vitro metabolism of 2-hydroxylamino-3-methylpyridine has been investigated using arochlor 1254 pretreated rat S9 mixtures. 2-Hydroxylamino-3-methylpyridine is rapidly converted to the parent amine 2-amino-3-methylpyridine. No further oxidation products of 2-hydroxylamino-3-methylpyridine (i.e. nitroso or nitro) were detected under the HPLC conditions used. This observation may explain our previous findings on the in vitro metabolism of 2-amino-3-methylpyridine where no hydroxylamino metabolite was detected.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Amino-3-methylpyridine, 95%