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  • Positive symptoms and water diffusivity of the prefrontal and temporal cortices in schizophrenia patients: a pilot study.

Positive symptoms and water diffusivity of the prefrontal and temporal cortices in schizophrenia patients: a pilot study.

Psychiatry research (2014-08-12)
Jin Young Park, Hae-Jeong Park, Dae-Jin Kim, Jae-Jin Kim
ABSTRACT

The development of diffusion tensor imaging (DTI) has provided information about microstructural changes in the brain. Most DTI studies have focused on white matter (WM). Few DTI studies have examined the gray matter (GM) in schizophrenia and, to date, there has been no attempt to identify the relationship between water diffusivity and symptom severity in schizophrenia. The present study aimed to examine microstructural deficits in the dorsal prefrontal cortex (DPFC) and temporal cortex in schizophrenia patients using fractional anisotropy (FA) and water diffusivity. This study also explored the relationship between DTI measurements and psychotic symptoms. Magnetic resonance imaging (MRI) and DTI were used to study 19 schizophrenia patients and 19 healthy controls. Fractional anisotropy, axial diffusivity, radial diffusivity, and regional volumes were measured in the prefrontal cortex and temporal cortex. On DTI measurements, patients showed increased axial and radial diffusivities in the prefrontal cortex and temporal cortex, but they did not demonstrate any difference in fractional anisotropy and regional volumes. Additionally, axial and radial diffusivities were significantly correlated with positive symptom scores in all regions of interest. These results indicate that water diffusivity measurements, including axial and radial diffusivities, can be used to identify microstructural changes in the gray matter in schizophrenia that may be related to symptom severity.

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Supelco
Water, for HPCE, for luminescence, suitable for UV/Vis spectroscopy
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Sigma-Aldrich
Water, tested according to Ph. Eur.
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Water, for cell biology, sterile ultrafiltered
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100 μg
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100 μg
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Water, for embryo transfer, sterile-filtered, BioXtra, suitable for mouse embryo cell culture
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100 μg
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Sigma-Aldrich
Water, Nuclease-Free Water, for Molecular Biology
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100 μg
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$429.00
Sigma-Aldrich
Water, sterile-filtered, BioReagent, suitable for cell culture
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100 μg
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$429.00
Supelco
Density Standard 998 kg/m3, H&D Fitzgerald Ltd. Quality
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100 μg
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$429.00
Sigma-Aldrich
Distilled water, suitable for HPLC
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100 μg
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$429.00
Supelco
Water, for TOC analysis
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100 μg
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$429.00
Supelco
Water, suitable for ion chromatography
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100 μg
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$429.00
Sigma-Aldrich
Water, for molecular biology, sterile filtered
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100 μg
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$429.00
Sigma-Aldrich
E-Toxate Water, endotoxin, free
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100 μg
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$429.00
Supelco
Water, ACS reagent, for ultratrace analysis
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100 μg
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Pure Water Density Standard, UKAS ISO/IEC17025 and ISO Guide 34 certified, density: 0.9982 g/mL at 20 °C, density: 0.9970 g/mL at 25 °C
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Pure Water Density Standard, UKAS ISO/IEC17025 and ISO Guide 34 certified, density: 0.9982 g/mL at 20 °C, density: 0.9970 g/mL at 25 °C
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100 μg
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$429.00
Sigma-Aldrich
Water, BioPerformance Certified
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100 μg
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$429.00
Sigma-Aldrich
Water, ACS reagent
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100 μg
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Sigma-Aldrich
Water, Deionized
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100 μg
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Sigma-Aldrich
Water, suitable for HPLC
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100 μg
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Sigma-Aldrich
Water, HPLC Plus
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