Interleukin-17A promotes the growth of human germinal center derived non-Hodgkin B cell lymphoma.

Interleukin-17A promotes the growth of human germinal center derived non-Hodgkin B cell lymphoma.

Oncoimmunology (2015-10-10)

Elisa Ferretti, Emma Di Carlo, Emanuela Ognio, Carla Guarnotta, Francesco Bertoni, Anna Corcione, Ignazia Prigione, Giulio Fraternali-Orcioni, Domenico Ribatti, Jean Louis Ravetti, Maurilio Ponzoni, Claudio Tripodo, Vito Pistoia

PMID26451300

ABSTRACT

Interleukin (IL)-17A belongs to IL-17 superfamily and binds the heterodimeric IL-17 receptor (R)(IL-17RA/IL-17RC). IL-17A promotes germinal center (GC) formation in mouse models of autoimmune or infectious diseases, but the role of IL-17A/IL-17AR complex in human neoplastic GC is unknown. In this study, we investigated expression and function of IL-17A/IL-17AR in the microenvironments of 44 B cell non-Hodgkin lymphomas (B-NHL) of GC origin (15 follicular lymphomas, 17 diffuse large B cells lymphomas and 12 Burkitt lymphomas) and 12 human tonsil GC. Furthermore, we investigated the role of IL-17A in two

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