CASP8
caspase 8, apoptosis-related cysteine peptidase
Synonyms:
ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Species:
Human CASP8 (841), Mouse Casp8 (12370), Rat Casp8 (64044), Horse CASP8 (100066502), Zebrafish casp8 (58022), chicken CASP8 (395284), naked mole-rat Casp8 (101702773), domestic guinea pig Casp8 (100713334), cow CASP8 (507481), sheep CASP8 (101107334) ...More
UniProtKB ID:
Gene ID:
- Human(841) Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
- Mouse(12370) caspase 8
- Rat(64044) caspase 8
- Horse(100066502) caspase 8, apoptosis-related cysteine peptidase
- Zebrafish(58022) caspase 8, apoptosis-related cysteine peptidase
- chicken(395284) caspase 8, apoptosis-related cysteine peptidase
- naked mole-rat(101702773) caspase 8, apoptosis-related cysteine peptidase
- domestic guinea pig(100713334) caspase 8, apoptosis-related cysteine peptidase
- cow(507481) caspase 8, apoptosis-related cysteine peptidase
- sheep(101107334) caspase 8, apoptosis-related cysteine peptidase
- dog(488473) caspase 8, apoptosis-related cysteine peptidase
- domestic cat(100142684) caspase 8, apoptosis-related cysteine peptidase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Caspase-8 Antibody, clone C15, ,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot
Anti-Cleaved Caspase-8 Antibody, clone 1K3 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Caspase 8 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti- Caspase-8 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-Caspase 8 antibody, Mouse monoclonal, clone CAS8, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
microarray
western blot
microarray
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
Caspase 8 human, ≥90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine tagged), buffered aqueous solution, ≥1,000 units/mg protein,
Species
human
esiRNA
Small Molecule - Substrate
Product Number
Description
Species
N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin, ≥97% (HPLC), powder,
Species
rat, mouse, human