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Key Documents

SCP0093

Sigma-Aldrich

Caspase Inhibitor

≥95% (HPLC)

Synonym(s):

Ac-LETD-CHO, caspase 8 inhibitor, caspase 9 inhibitor

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About This Item

Empirical Formula (Hill Notation):
C21H34N4O10
Molecular Weight:
502.52
UNSPSC Code:
12352200
NACRES:
NA.32

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Gene Information

Amino Acid Sequence

Ac-Leu-Glu-Thr-Asp-al

Application

Caspase inhibitor Ac-LETD-CHO has been used to inhibit caspase-8.

Biochem/physiol Actions

The peptide Ac-Leu-Glu-Thr-Asp-al, or Ac-LETD-CHO, is a known caspase inhibitor. Ac-LETD-CHO has been reported to exert inhibitory effects on caspase 8 and on caspase 9.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jie Shi et al.
Biochemical pharmacology, 75(9), 1729-1742 (2008-04-02)
Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti-cancer function. I3M has been well established as a cyclin-dependent kinase (CDK) inhibitor, while the molecular mechanism underlying I3M-induced apoptosis has not been
Apoptotic Regulation of Caspase Activity
Martinova, E.A., et al.
Russian J. Bioorg. Chem., 29, 471-495 (2003)
Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways
Lara M
Scientific Reports (2017)
Preventive Effects of Food Components on Caspase-8-Mediated Apoptosis Induced by Dietary Carcinogen, Trp-P-1, in Rat Mononuclear Cells
Hashimoto, T., et al.
ACS Symp. Ser., 851, 128-140 (2003)
Takashi Araki et al.
Nephron. Experimental nephrology, 93(3), e117-e124 (2003-03-28)
Programmed cell death is a mechanism by which organisms dispose of unwanted cells, and it is thought to be an important process in organogenesis. We have already reported the role of caspase-3 in the developing metanephros. While caspase-3 is thought

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