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Merck

TOP1MT

topoisomerase (DNA) I, mitochondrial

Synonymes:
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(116447) Summary: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
  • Mouse(72960) DNA topoisomerase 1, mitochondrial
  • Rat(300029) topoisomerase (DNA) I, mitochondrial
  • domestic guinea pig(100728586) topoisomerase (DNA) I, mitochondrial
  • Zebrafish(415098) mitochondrial topoisomerase I
  • cow(618382) topoisomerase (DNA) I, mitochondrial
  • chicken(408025) topoisomerase (DNA) I, mitochondrial
  • naked mole-rat(101726319) topoisomerase (DNA) I, mitochondrial
  • sheep(101114532) topoisomerase (DNA) I, mitochondrial

Custom & Knockdown Gene Products

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-TOP1MT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-TOP1MT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Inhibitor

Numéro du produit
Description
Espèce(s)
Topotecan hydrochloride hydrate, ≥98% (HPLC and enzymatic),
Espèce(s)
human

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human TOP1MT,
Espèce(s)
human
MISSION® esiRNA, targeting human TOP1MT (2),
Espèce(s)
human