ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
Synonyms:
SRK, STCD, STD, TZK, ZAP-70
Species:
Human ZAP70 (7535), Mouse Zap70 (22637), Rat Zap70 (301348), dog ZAP70 (100271860), domestic cat ZAP70 (101097059), chicken ZAP70 (420086), Zebrafish zap70 (553615), sheep ZAP70 (101112639), Domestic Rabbit ZAP70 (100342021), naked mole-rat Zap70 (101716577) ...More
UniProtKB ID:
Gene ID:
- Human(7535) Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(22637) zeta-chain (TCR) associated protein kinase
- Rat(301348) zeta-chain (TCR) associated protein kinase 70
- dog(100271860) zeta-chain (TCR) associated protein kinase 70kDa
- domestic cat(101097059) zeta-chain (TCR) associated protein kinase 70kDa
- chicken(420086) zeta-chain (TCR) associated protein kinase 70kDa
- Zebrafish(553615) zeta-chain (TCR) associated protein kinase
- sheep(101112639) zeta-chain (TCR) associated protein kinase 70kDa
- Domestic Rabbit(100342021) zeta-chain (TCR) associated protein kinase 70kDa
- naked mole-rat(101716577) zeta-chain (TCR) associated protein kinase 70kDa
- domestic guinea pig(100713473) zeta-chain (TCR) associated protein kinase 70kDa
- cow(504509) zeta-chain (TCR) associated protein kinase 70kDa
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ZAP70 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-ZAP-70 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
western blot
western blot
Anti-ZAP-70 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
immunohistochemistry
Anti-ZAP-70 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ZAP-70, antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
immunohistochemistry
Proteins
Product Number
Description
Species
ZAP-70 Tyrosine Kinase human, ≥90% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells (Histidine tagged), buffered aqueous glycerol solution, ≥150 U/mg,
Species
human
ZAP-70 Protein, active, 20 µg, Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.,
Species
human