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746371

Sigma-Aldrich

Sodium iodide

anhydrous, free-flowing, Redi-Dri™, ACS reagent, ≥99.5%

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About This Item

Linear Formula:
NaI
CAS Number:
7681-82-5
Molecular Weight:
149.89
EC Number:
231-679-3
MDL number:
MFCD00003532
UNSPSC Code:
12352302
PubChem Substance ID:
329765763
NACRES:
NA.21

grade

ACS reagent
anhydrous

Quality Level

100

vapor density

>1 (vs air)

product line

Redi-Dri™

assay

≥99.5%

form

powder

quality

free-flowing

impurities

≤0.002% N compounds
≤0.01% insolubles

pH

6.0-9.0 (25 °C, 5%)

mp

661 °C (lit.)

anion traces

Cl- and Br-: ≤0.01%
iodate (IO3-): ≤3 ppm
phosphate (PO43-): ≤0.001%
sulfate (SO42-): ≤0.005%

cation traces

Ba: ≤0.002%
Ca: ≤0.002%
Fe: ≤5 ppm
K: ≤0.01%
Mg: ≤0.001%
heavy metals (as Pb): ≤5 ppm

SMILES string

[Na+].[I-]

InChI

1S/HI.Na/h1H;/q;+1/p-1

InChI key

FVAUCKIRQBBSSJ-UHFFFAOYSA-M

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General description

Sodium iodide is an inorganic sodium salt that is commonly used as a source of iodide ions in organic synthesis. It is used in the conversion of alkyl halides and sulfonates into alkyl iodides and aryl iodides via nucleophilic displacement reactions. Additionally, NaI is also used in combination with oxidizing agents for the iodination of organoboranes, phenols, and aromatic compounds.

Application

Sodium iodide can be used in the following:      
  • NaI-AlCl3 is used as a dehydrating agent in the Beckmann rearrangement of ketoximes to anilides.      
  • NaI-cerium chloride supported on silica gel is used as a catalyst for the synthesis of 2,3-dihydro-1H-1,5-benzodiazepines by the reaction of o-phenylenediamines and ketones.      
  • NaI-dichlorodimethylsilane catalytic system is used for the reduction of diarylmethanols to corresponding diarylmethanes.

Features and Benefits

  • Increased efficiency – Eliminates time and effort of loosening hardened powders     
  • Safety – Eliminates tools of force used to break up clumps
  • Ecology – Reduces waste as it does not stick to the packaging      
  • Economy – Faster preparation and solvation increase productivity and reduce costs      
  • Assured Quality – Excellent, expert-tested quality with no anti-caking agents      
  • Flexible volumes – Available from research amounts to scale-up quantities

Legal Information

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Takuro Isoda et al.
Clinical nuclear medicine, 39(8), 680-684 (2014-07-01)
Many cases of unexpected radioiodine uptake have been reported, including physiological uptake in healthy tissue and in both benign and malignant nonthyroidal lesions. However, iodine uptake in the uterus has not been well assessed. In this article, we systemically analyzed
Dafu Yu et al.
Hormones and behavior, 69, 106-115 (2015-01-28)
Thyroid hormone disorders have long been linked to depression, but the causal relationship between them remains controversial. To address this question, we established rat models of hypothyroidism using (131)iodine ((131)I) and hyperthyroidism using levothyroxine (LT4). Serum free thyroxine (FT4) and
Anke de Vries et al.
Investigative radiology, 50(4), 297-304 (2015-01-01)
The objective of this study was to investigate the feasibility and the accuracy of spectral computed tomography (spectral CT) to determine the tissue concentrations and localization of high-attenuation, iodine-based contrast agents in mice. Iodine tissue concentrations determined with spectral CT
Zhibo Liu et al.
Molecular pharmaceutics, 12(3), 974-982 (2015-01-30)
Bradykinin B1 receptor (B1R) is involved in pain and inflammation pathways and is upregulated in inflamed tissues and cancer. Due to its minimal expression in healthy tissues, B1R is an attractive target for the development of therapeutic agents to treat
Mohamed Touati et al.
Leukemia & lymphoma, 56(2), 332-341 (2014-04-29)
Finding new prognostic factors to identify patients with Hodgkin lymphoma (HL) at risk of treatment resistance or relapse remains challenging in daily practice. We evaluated the relationship between CD68 expression, interim positron emission tomography (iPET) results and outcome in 158
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