Skip to Content
MilliporeSigma
All Photos(2)

Key Documents

SAB3500666

Sigma-Aldrich

Anti-TRMT12 antibody produced in rabbit

affinity isolated antibody

Sign Into View Organizational & Contract Pricing

Select a Size

100 μL
$457.00

$457.00


Estimated to ship onMarch 23, 2025

A recombinant, preservative-free antibody is available for your target. Try ZRB1565


Select a Size

Change View
100 μL
$457.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$457.00


Estimated to ship onMarch 23, 2025

A recombinant, preservative-free antibody is available for your target. Try ZRB1565

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

mol wt

49 kDa

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

ELISA: suitable
immunocytochemistry: suitable
western blot: suitable

UniProt accession no.

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
W24880047910798673
organoleptic

odorless

organoleptic

odorless

organoleptic

-

organoleptic

-

biological source

botanical

biological source

synthetic

biological source

-

biological source

-

food allergen

no known allergens

food allergen

no known allergens

food allergen

-

food allergen

-

documentation

see Safety & Documentation for available documents

documentation

see Safety & Documentation for available documents

documentation

-

documentation

-

assay

≥98%

assay

-

assay

≥99.0% (T)

assay

≥99%

General description

TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase.

Immunogen

Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2.

Biochem/physiol Actions

TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500666.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Not finding the right product?  

Try our Product Selector Tool.

related product

Product No.
Description
Pricing

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

TRMT12 overexpression in cancer cells affects the cell cycle and the nonsense mediated decay pathways by regulating the SMG-1 kinase, a member of the PIKK family of kinases.
Rodriguez V et al
Cancer Research, 69(9), 2486-2486 (2009)
Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer.
Rodriguez V et al
Genes Chromosomes Cancer, 46(7), 694-707 (2007)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service