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Key Documents

T3382

Sigma-Aldrich

Lipopolysaccharides from Escherichia coli O111:B4

trinitrophenyl conjugate

Synonym(s):

LPS

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352201

biological source

Escherichia coli (O111:B4)

conjugate

trinitrophenyl conjugate

form

lyophilized powder

extent of labeling

10-60 μg trinitrophenol per mg LPS

shipped in

ambient

storage temp.

2-8°C

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Application

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Thiago Alves Teixeira dos Santos et al.
PloS one, 6(11), e27867-e27867 (2011-12-06)
Phosphatidylserine (PS) exposure on the cell surface indicates apoptosis, but has also been related to evasion mechanisms of parasites, a concept known as apoptotic mimicry. Toxoplasma gondii mimics apoptotic cells by exposing PS, inducing secretion of TGF-beta1 by infected activated
Elisabeth G Vichaya et al.
Brain, behavior, and immunity, 23(7), 969-976 (2009-05-14)
Recent research indicates that glial cells control complex functions within the nervous system. For example, it has been shown that glial cells contribute to the development of pathological pain, the process of long-term potentiation, and the formation of memories. These
Marcus Mühlbauer et al.
Immunology, 124(2), 256-264 (2008-02-21)
Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial
Katherine E Wickliffe et al.
Cellular microbiology, 10(6), 1352-1362 (2008-02-13)
Macrophages from certain inbred mouse strains are rapidly killed (< 90 min) by anthrax lethal toxin (LT). LT cleaves cytoplasmic MEK proteins at 20 min and induces caspase-1 activation in sensitive macrophages at 50-60 min, but the mechanism of LT-induced
Amanda M Enstrom et al.
Brain, behavior, and immunity, 24(1), 64-71 (2009-08-12)
Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. Recent evidence has suggested that impairments of innate immunity may play an important role in ASD. To test this hypothesis, we

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