A2754

Adenosine 5′-diphosphate sodium salt

bacterial, ≥95% (HPLC)

• Synonym(s): ADP sodium salt, ADP
• Empirical Formula (Hill Notation): C₁₀H₁₅N₅O₁₀P₂
• CAS Number: 20398-34-9
• Molecular Weight: 427.20
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24890690
• NACRES: NA.51

Properties

• biological source: bacterial
• assay: ≥95% (HPLC)
• form: powder
• storage temp.: −20°C
• SMILES string: [Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O
• InChI: 1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
• InChI key: XTWYTFMLZFPYCI-KQYNXXCUSA-N
• Gene Information: human ... HSP90AA1(3320) , P2RY1(5028)

Description

General description

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

Application

Adenosine 5′-diphosphate sodium salt has been used:

• as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin by aggregometery.
• in the preparation of stock solution for a mito stress test.
• as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets.
• as a platelet agonist to stimulate platelet aggregation.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable