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A5285

Sigma-Aldrich

Adenosine 5′-diphosphate monopotassium salt dihydrate

bacterial, ≥95%, powder

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Synonym(s):
Adenosine 5′-Diphosphate Potassium Salt, ADP
Empirical Formula (Hill Notation):
C10H14KN5O10P2 · 2H2O
CAS Number:
Molecular Weight:
501.32
MDL number:
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.77

biological source

bacterial

Quality Level

assay

≥95%

form

powder

storage temp.

−20°C

SMILES string

[O-]P(OP(OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N2C3=C(N=C2)C(N)=NC=N3)(O)=O)(O)=O.[K+]

InChI

1S/C10H15N5O10P2.K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1

InChI key

ZNCWUOPIJTUALR-MCDZGGTQSA-M

Gene Information

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This Item
A6885M3763A8016
form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

biological source

bacterial

biological source

-

biological source

synthetic (organic)

biological source

-

Gene Information

human ... HSP90AA1(3320), P2RY1(5028)

Gene Information

-

Gene Information

-

Gene Information

-

General description

Adenosine diphosphate (ADP) is a crucial component for energy flow in living organisms. Its structure consists of a sugar backbone connected to adenine and two phosphate groups attached to the fifth carbon atom of the ribose sugar. ADP serves a precursor for ATP biosynthesis. ADP acts as a weak platelet agonist, specifically targeting the P2Y receptor. However, ADP plays a vital role in platelet function by enhancing the effects of other platelet agonists and promoting the stability of platelet aggregates when released from platelet dense granules.

Application

Adenosine 5′-diphosphate has been used to study the release, neuronal effects, and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain. Adenosine 5′-diphosphate has also been used to compare prasugrel versus clopidogrel antiplatelet therapy after acute coronary syndrome.
Adenosine 5′-diphosphate monopotassium salt dihydrate (ADP) has been used:
  • in titration to determine complex I-supported respiration in permeabilized muscle fibers
  • in titrations to determine ADP-stimulated respiratory kinetics
  • in the preparation of ADP solution for measuring mitochondrial respiration

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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The Platelet P2 Receptors
Cattaneo M
Platelets (2013)
Daniel S Ziemianowicz et al.
Journal of the American Society for Mass Spectrometry, 31(2), 207-216 (2020-02-08)
The functional properties of a protein are strongly influenced by its topography, or the solvent-facing contour map of its surface. Together with crosslinking, covalent labeling mass spectrometry (CL-MS) has the potential to contribute topographical data through the measurement of surface
Roles of AMP, ADP, ATP, and AMPK in Healthy Energy Boosting and Prolonged Life Span
Yadav D , et al.
Chemistry & Biology (2017)
Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity
Hardee JP, et al.
Molecular Metabolism (2021)
Leonie Durnin et al.
The European journal of neuroscience, 35(3), 423-435 (2012-01-27)
Recent evidence supports an emerging role of β-nicotinamide adenine dinucleotide (β-NAD(+) ) as a novel neurotransmitter and neuromodulator in the peripheral nervous system -β-NAD(+) is released in nerve-smooth muscle preparations and adrenal chromaffin cells in a manner characteristic of a

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