810189P

TopFluor^™ PI(3,4,5)P3

Avanti Research^™ - A Croda Brand 810189P, powder

• 別名: 1-oleoyl-2-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-sn-glycero-3-phosphoinositol-3,4,5-trisphosphate (ammonium salt)
• 実験式（ヒル表記法）: C₅₆H₁₀₈ BF₂ N₇O₂₃P₄
• CAS番号: 2260795-37-5
• 分子量: 1420.19
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• アッセイ: >99% (TLC)
• 形状: powder
• 包装: pkg of 1 × 50 μg (with stopper and crimp cap (810189P-50ug))
• メーカー／製品名: Avanti Research^™ - A Croda Brand 810189P
• 輸送温度: dry ice
• 保管温度: −20°C

詳細

詳細

PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor^™ PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain.

Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid present on the inner leaflet of the plasma membrane.

生物化学的／生理学的作用

PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor^™ PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores.

Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals. It also regulates the activity protein kinase B/Akt.

包装

2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

TopFluor is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable