04-001

Anti-JAK2 Antibody, clone 8E10.2

clone 8E10.2, Upstate^®, from mouse

• 別名: Janus kinase 2, Tyrosine kinase
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.43
• クローン: 8E10.2, monoclonal
• application: IHC; WB
• 化学種の反応性: mouse, human, rat
• テクニック: immunohistochemistry: suitable (paraffin); western blot: suitable
• citations: 9

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: 8E10.2, monoclonal
• 化学種の反応性: mouse, human, rat
• 包装: antibody small pack of 25 μg
• メーカー／製品名: Upstate^®
• テクニック: immunohistochemistry: suitable (paraffin); western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_004963
• UniProtアクセッション番号: O60674
• 輸送温度: ambient
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... JAK2(3717) ; mouse ... Jak2(16452) ; rat ... Jak2(24514)

詳細

詳細

JAK2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerizes and translocates to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

特異性

This antibody recognizes Jak2.

免疫原

KLH-conjugated linear peptide.

アプリケーション

Research Category
炎症及び免疫

Research Sub Category
免疫シグナル伝達

Western Blot Analysis: 0.5-1 μg/mL of this lot was used to detect Jak2 in L6 cell lysates.

Immunohistochemistry(Paraffin):
A previous lot of this antibody was used in immunohistochemistry(paraffin) staining with eptiope retrieval: Human Cancer Array.

Anti-JAK2 Antibody, clone 8E10.2 detects level of JAK2 & has been published & validated for use in WB, IH(P).

品質

Routinely evaluated by western blot on L6 cell lysate.

ターゲットの説明

130 kDa

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH7.4), 150 mM NaCl with 0.05% sodium azide

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
L6 cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.