05-23-0600

Substance P

Neuropeptide found in high concentrations in the gut.

• 別名: Substance P, Neurokinin P, RPKPQQFFGLM, SP
• 実験式（ヒル表記法）: C₆₃H₉₈N₁₈O₁₃S
• CAS番号: 33507-63-0
• 分子量: 1347.63
• MDL番号: MFCD00076780
• UNSPSCコード: 12352202
• NACRES: NA.51

特性

• 品質水準: 100
• アッセイ: ≥96% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: 5% acetic acid: 1 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]3N(CCC3)C(=O)[C@@H](NC(=O)[C@H]4N(CCC4)C(=O)[C@@H](N)CCCN=C(N)N)CCCCN)CCC(=O)N)CCC(=O)N)Cc2ccccc2)Cc1ccccc1)CC(C)C)C(=O)N)C
• InChI: 1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
• InChI Key: ADNPLDHMAVUMIW-CUZNLEPHSA-N

詳細

詳細

Substance P (SP) is an 11-amino acid neuropeptide belonging to the tachykinin (TAC) family of neuropeptides. It is encoded by the TAC1 gene in the central nervous system (CNS), the peripheral nervous system, and immune cells. Moreover, it serves essential functions in inflammation, angiogenesis, and wound healing. It is also found in high concentrations in the gut. When released from afferent nerves, it causes a neurogenic inflammatory response, including mast cell degranulation. It is known to induce Ca2+ mobilization and reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.

アプリケーション

Substance P (SP) has been used to enhance the lipid accumulation in 3T3‑L1 cells as they undergo differentiation into adipocytes in the presence of elevated glucose levels.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Substance P receptors

Product does not compete with ATP.

Reversible: no

包装

Yes

警告

Toxicity: Standard Handling (A)

シーケンス

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable