118415

ADP-HPD, Dihydrate, Ammonium Salt

≥95% (HPLC), lyophilized solid, PARG inhibitor, Calbiochem^®

• 別名: ADP-HPD, Dihydrate, Ammonium Salt, Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
• 実験式（ヒル表記法）: C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
• 分子量: 595.39
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: ADP-HPD, Dihydrate, Ammonium Salt, ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM).
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white
• 溶解性: water: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC₅₀ = 120 nM) vs. ADP-ribose (IC₅₀ = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Note: 1 set = 5 x 60 µg.

Note: 1 set = 5 x 60 µg

生物化学的／生理学的作用

Cell permeable: no

Primary Target
PARG

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 120 nM against poly(ADP-ribose) glycohydrolase (PARG)

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

その他情報

Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem.38, 389.
Slama, J.T., et al. 1995. J. Med. Chem.38, 4332.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable