218705

Casein Kinase I Inhibitor, D4476

InSolution, ≥95%

• 別名: InSolution Casein Kinase I Inhibitor, D4476
• 実験式（ヒル表記法）: C₂₃H₁₈N₄O₃
• 分子量: 398.41
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

詳細

A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC₅₀ = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC₅₀ = 500 nM). A weak inhibitor of p38α MAP kinase (IC₅₀ = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser³²² and Ser³²⁵) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC₅₀ = 2.5 µM for CK1).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
CK1, CK1d

Product competes with ATP.

Reversible: no

Target IC₅₀: 0.2 µM, 0.3 µM against CK1, CK1d, respectively

包装

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Irritant (B)

物理的形状

A 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO

再構成

Following initial use, aliquot and refrigerate (4°C).

その他情報

Rena, G., et al. 2004. EMBO Reports5, 60.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany