368055

Granzyme B Inhibitor II

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

• 別名: Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO
• 実験式（ヒル表記法）: C₂₁H₃₄N₄O₁₀
• CAS番号: 1258003-96-1
• 分子量: 502.52
• MDL番号: MFCD01318858
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: 1 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: N([C@@H]([C@@H](O)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)[C@H](CC)C)CCC(=O)O

詳細

詳細

A potent, reversible inhibitor of granzyme B and caspase-8 (K_i = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).

Potent, reversible granzyme B and caspase-8 inhibitor.

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target K_i: 1 nM against caspase-8

警告

Toxicity: Standard Handling (A)

シーケンス

Ac-Ile-Glu-Thr-Asp-CHO

その他情報

Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable