368056

Granzyme B Inhibitor IV

The Granzyme B Inhibitor IV controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

• 別名: Granzyme B Inhibitor IV, Ac-IEPD-CHO, Caspase-8 inhibitor III
• 実験式（ヒル表記法）: C₂₂H₃₄N₄O₉
• 分子量: 498.53
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A reversible inhibitor of Granzyme B that also inhibits caspase-8. Granzyme B is a protease involved in the induction of rapid target cell death by cytotoxic lymphocytes.

A reversible inhibitor of granzyme B and caspase-8.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
granzyme B

Product does not compete with ATP.

Reversible: yes

警告

Toxicity: Standard Handling (A)

シーケンス

Ac-Ile-Glu-Pro-Asp-CHO

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Harris, J.L., et al. 1998. J. Biol. Chem. 273, 27364.
Thornberry, N.A., et al. 1997. J. Biol. Chem.272, 17907.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable