382172

Histone Deacetylase Inhibitor VI, HNHA

The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase.

• 別名: Histone Deacetylase Inhibitor VI, HNHA, N-Hydroxy-7-(2-naphthylthio)heptanomide
• 実験式（ヒル表記法）: C₁₇H₂₁NO₂S
• CAS番号: 926908-04-5
• 分子量: 303.42
• MDL番号: MFCD10568146
• UNSPSCコード: 12352200
• NACRES: NA.54

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: methanol: 10 mg/mL; DMSO: 100 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: S(CCCCCCC(=O)NO)c1cc2c(cc1)cccc2
• InChI: 1S/C17H21NO2S/c19-17(18-20)9-3-1-2-6-12-21-16-11-10-14-7-4-5-8-15(14)13-16/h4-5,7-8,10-11,13,20H,1-3,6,9,12H2,(H,18,19)
• InChI Key: KPNNXHVGOKRBEF-UHFFFAOYSA-N

詳細

詳細

A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC₅₀ = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun.356, 233.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable