382175-M

Histone Deacetylase Inhibitor VIII

The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 別名: Histone Deacetylase Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid, HDAC Inhibitor VIII
• 実験式（ヒル表記法）: C₂₂H₃₀N₄O₆
• CAS番号: 1045792-66-2
• 分子量: 446.50
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: beige to light brown
• 溶解性: DMSO: 50 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
• InChI Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N

詳細

詳細

A cell-permeable, active site Zn²⁺-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC₅₀ = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC₅₀<1.0 µM).

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Kozikowski, A.P., et al. 2008. J. Med. Chem.51, 4370.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable