385920

HSP90 Inhibitor, CCT018159

The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.

• 別名: HSP90 Inhibitor, CCT018159, 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
• 実験式（ヒル表記法）: C₂₀H₂₀N₂O₄
• CAS番号: 171009-07-7
• 分子量: 352.38
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: water: 1.7 mg/mL; DMSO: 35 mg/mL; ethanol: 35 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C20H20N2O4/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22)
• InChI Key: OWPMENVYXDJDOW-UHFFFAOYSA-N

詳細

詳細

A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC₅₀ = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme′s N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.

その他情報

Hardcastle, A., et al. 2007. Mol. Cancer Ther.6, 1112.
Sharp, S.Y., et al. 2007. Cancer Res.67, 2206.
Smith, N.F., et al. 2006. Mol. Cancer Ther.5, 1628.
Dymock, B.W., et al. 2005. J. Med. Chem.48, 4212.
Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett.15, 3338.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable