444294-M

MMP-2 Inhibitor IV

The MMP-2 Inhibitor IV controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: MMP-2 Inhibitor IV, (4′-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid, Bone Resorption Inhibitor, Bone Resorption Inhibitor, (4′-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
• 実験式（ヒル表記法）: C₁₃H₁₄ClNO₈P₂S
• 分子量: 441.72
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 100 mg/mL, clear, colorless
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC₅₀ = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (>1 M), and MMP-14 (>1 M). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC₅₀ = 1.7 M), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC₅₀ = 30 M), and Zolendronate (7.8 M), without observable cytotoxicity in HepG2 cells. At 25 M, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Rubino, M.T., et al. 2011. Chem. Med. Chem.6, 1258.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable