444286-M

MMP-2 Inhibitor II

The MMP-2 Inhibitor II, also referenced under CAS 869577-51-5, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: MMP-2 Inhibitor II, (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane
• 実験式（ヒル表記法）: C₁₆H₁₇NO₆S₂
• CAS番号: 869577-51-5
• 分子量: 383.44
• MDL番号: MFCD24369005
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• 有効性: 2.4 μM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated; protect from light
• 色: white
• 溶解性: DMSO: 200 mg/mL
• 保管温度: −20°C
• SMILES記法: [S](=O)(=O)(Nc1ccc(cc1)Oc2ccc(cc2)[S](=O)(=O)CC3OC3)C
• InChI: 1S/C16H17NO6S2/c1-24(18,19)17-12-2-4-13(5-3-12)23-14-6-8-16(9-7-14)25(20,21)11-15-10-22-15/h2-9,15,17H,10-11H2,1H3
• InChI Key: ADEXXMLIERNFQB-UHFFFAOYSA-N

詳細

詳細

An oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (K_i = 2.4 µM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (K_i = 45 and 379 µM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS.

生物化学的／生理学的作用

Secondary Target
MMP-2 (K_i = 45 and 379 µM for MMP-1 and MMP-7, respectively)

警告

Toxicity: Standard Handling (A)

その他情報

Ikejiri, M., et al. 2005. J. Biol. Chem.280, 33992.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable