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製品名
PP2, InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases
品質水準
アッセイ
≥95% (HPLC)
フォーム
liquid
メーカー/製品名
Calbiochem®
保管条件
OK to freeze
protect from light
色
clear colorless
輸送温度
wet ice
保管温度
−20°C
詳細
A potent and selective inhibitor of the src family of tyrosine kinases. Its action is similar to PP1. Selectively inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), and Hck (IC50 = 5 nM) compared to other tyrosine kinases, such as EGF-R (IC50 = 480 nM), JAK2 (IC50 >50 µM) or ZAP-70 (IC50 >100 µM). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM).
生物化学的/生理学的作用
Cell permeable: no
Primary Target
p56lck
p56lck
Product competes with ATP.
Reversible: yes
Target IC50: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
物理的形状
A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529573) in DMSO.
再構成
Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
その他情報
Hanke, J.H., et al. 1996. J. Biol. Chem.271, 695.
Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.
Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
引火点(℃)
87 °C - closed cup - (Dimethylsulfoxide)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
消防法
第4類:引火性液体
第三石油類
危険等級III
非水溶性液体
労働安全衛生法名称等を表示すべき危険物及び有害物
名称等を表示すべき危険物及び有害物
労働安全衛生法名称等を通知すべき危険物及び有害物
名称等を通知すべき危険物及び有害物
Jan Code
529576-1MG:
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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