616521

TRPV4 Antagonist II, HC-067047

The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4.

• 別名: TRPV4 Antagonist II, HC-067047, 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047, HC067047, 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II
• 実験式（ヒル表記法）: C₂₆H₂₈F₃N₃O₂
• CAS番号: 883031-03-6
• 分子量: 471.51
• MDL番号: MFCD01571257
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 50 mg/mL, clear, colorless
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: FC(F)(F)c1cc(ccc1)NC(=O)c2c([n](c(c2)c4ccccc4)CCCN3CCOCC3)C
• InChI Key: NCZYSQOTAYFTNM-UHFFFAOYSA-N

詳細

詳細

A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC₅₀ = 17, 48, and 133 nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC₅₀ = 368 and 780 nM, respectively) and little or no activity toward hK_v1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rK_v1.2. HC-067047 is efficacious (10 mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA- (Cat. No. 239785) induced cystitis in vivo.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Everaerts, W., et al. 2010. Proc. Natl. Acad. Sci. USA107, 19084.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable