AB2281

Anti-Na+K+Cl- Cotransporter 2 Antibody

from rabbit, purified by affinity chromatography

• 別名: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, NKCC2A variant A, Na-K-2Cl cotransporter, sodium potassium chloride cotransporter 2, solute carrier family 12 (sodium/potassium/chloride transporters), m
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: mouse, rat, human
• テクニック: western blot: suitable
• NCBIアクセッション番号: NM_000338.2
• UniProtアクセッション番号: Q13621
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SLC12A1(6557)

詳細

詳細

The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle′s loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. SLC12A1 is kidney specific and is essential in the regulation of ionic balance and cell volume. It is a component of an electrically silent transporter system, mediating sodium and chloride reabsorption. Defects in SLC12A1 are the cause of Bartter syndrome type 1, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria.

特異性

This antibody recognizes the cytoplasmic domain of NA+K+CL- Cotransporter 2.

免疫原

Epitope: Cytoplasmic domain

KLH conjugate followed by NA+K+CL- Cotransporter 2 corresponding to the cytoplasmic domain.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
イオンチャネル及びトランスポーター

Anti-Na+K+Cl-Cotransporter 2 Antibody detects level of Na+K+Cl-Cotransporter 2 & has been published & validated for use in WB.

品質

Western Blot Analysis:
1:2,000 dilution of this lot detected NA+K+CL- Cotransporter 2 on 10 µg of rat liver lysate.

ターゲットの説明

~150 kDa

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

保管および安定性

Stable for 1 year at 2-8ºC from date of receipt.

アナリシスノート

Control
Rat liver lysates

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable