ABC42-M

Anti-Mitofusin-2 (Mfn2) Antibody

from rabbit, purified by affinity chromatography

• 別名: Mitofusin-2, Transmembrane GTPase MFN2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• クローン: polyclonal
• application: WB
• 化学種の反応性: rat, human
• テクニック: western blot: suitable
• citations: 1

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: rat, human
• 化学種の反応性（ホモロジーによる予測）: mouse (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_055689
• UniProtアクセッション番号: O95140
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... MFN2(9927)

詳細

詳細

Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.

特異性

This antibody recognizes Mitofusin-2 (Mfn2) at the coiled coil region of the cytoplasmic domain.

免疫原

Epitope: Coiled Coil Region of the Cytoplasmic Domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Mitofusin-2 (Mfn2).

アプリケーション

Detect Mitofusin-2 (Mfn2) using this Anti-Mitofusin-2 (Mfn2) Antibody validated for use in WB.

品質

Evaluated by Western Blot in human heart tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitofusion-2 (Mfn2) in 10 µg of human heart tissue lysate.

ターゲットの説明

~86 kDa observed.
Mitofusion-2 (Mfn2) exists as 2 isoforms produced by alternative splicing with molecular weights of ~86 kDa and ~50 kDa

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable