MABS279

Anti-GPR30, clone 2F2 Antibody

clone 2F2, from mouse

• 別名: G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, LYGPR
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• クローン: 2F2, monoclonal
• application: IHC; IP
• 化学種の反応性: human
• テクニック: immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• citations: 1

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 2F2, monoclonal
• 化学種の反応性: human
• テクニック: immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_001035055
• UniProtアクセッション番号: Q99527
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GPER1(2852)

詳細

詳細

GPR30, also known as G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1 (FEG-1), G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor (LYGPR), or Membrane estrogen receptor (mER), and encoded by the gene GPER/CEPR/CMKRL2/DRY12/GPR30,is the common receptor for estrogen. GPR30 binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus, and therefore GPR30 is part of the rapid non-genomic signaling events widely observed when cells interact with estrogen. GPR30 is a cell membrane bound protein found in the Golgi apparatus, endoplasmic reticulum and plasma membrane. GPR30 is ubiquitously expressed, but is most abundant in placenta. In brain regions, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.

免疫原

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human GPR30.

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
GPCR、cAMP/cGMP及びカルシウムシグナル伝達

Detect GPR30 using this Anti-GPR30 antibody, clone 2F2 validated for use in IHC & IP.

Immunoprecipitation Analysis: A representative lot from an independent laboratory detected GPR30 in HEK293 cell lysate (Filardo, E., et al. (2007). Endocrinology. 148(7):3236-3245.).

品質

Evaluated by Immunohistochemistry in human placenta tissues.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected GPR30 in human placenta tissues.

ターゲットの説明

42 kDa calculated

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable