B1542

[Lys-des-Arg⁹]-ブラジキニン

≥95% (HPLC)

• 別名: des-Arg¹⁰-カリジン
• 実験式（ヒル表記法）: C₅₀H₇₃N₁₃O₁₁
• CAS番号: 71800-36-7
• 分子量: 1032.20
• MDL番号: MFCD00079826
• UNSPSCコード: 12352209
• PubChem Substance ID: 329773191
• NACRES: NA.32

特性

• 品質水準: 200
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• UniProtアクセッション番号: P01042
• 保管温度: −20°C
• SMILES記法: NCCCC[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(O)=O
• InChI: 1S/C50H73N13O11/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
• InChI Key: AILVBOHFGXNHCC-TZPCGENMSA-N
• 遺伝子情報: human ... KNG1 (includes EG:3827)

詳細

Amino Acid Sequence

Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

アプリケーション

[Lys-des-Arg9]-Bradykinin has been used as a B1R agonist to investigate the role of B1R in diabetes-induced secondary hemorrhage.

生物化学的／生理学的作用

[Des-Arg10]-kallidin or [Lys-des-Arg9]-Bradykinin is a bradykinin B1 receptor agonist. It strongly upregulates the B1 receptor and is blocked by a specific protein kinase C inhibitor. The upregulation is correlated with the induction of transcription nuclear factor κB (NF-κB). Elevation of Lys-des[Arg9]–bradykinin because of airway inflammation in asthma patients is known to modify the immune responses. It affects the migration and production of interleukin-12 in monocyte-derived dendritic cells.

その他情報

Lyophilized from 0.1% TFA in H2O

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)