B9031

(−)-ビロバリド Ginkgo biloba（イチョウ）葉由来

≥93% (HPLC)

• 別名: Bilobalide
• 実験式（ヒル表記法）: C₁₅H₁₈O₈
• CAS番号: 33570-04-6
• 分子量: 326.30
• MDL番号: MFCD00238547
• UNSPSCコード: 85151701
• PubChem Substance ID: 24892116
• NACRES: NA.28

特性

• 由来生物: plant leaves (Ginkgo biloba)
• 品質水準: 100
• アッセイ: ≥93% (HPLC)
• 形状: powder
• テクニック: HPLC: suitable
• 色: white
• 保管温度: −20°C
• SMILES記法: CC(C)(C)[C@]1(O)CC2OC(=O)C[C@@]23C(=O)OC4OC(=O)[C@H](O)[C@]134
• InChI: 1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1
• InChI Key: MOLPUWBMSBJXER-YDGSQGCISA-N

詳細

詳細

Bilobalide is a biologically active terpenic trilactone (terpenoid) extracted from Ginkgo biloba. It is synthesized from geranylgeranyl pyrophosphate (GGPP).

アプリケーション

(-)-Bilobalide from Ginkgo biloba leaves has been used as a reference substance to study the antimicrobial activity of different fractions of G.biloba leaves against a number of Gram-positive and negative bacteria and yeasts.

生物化学的／生理学的作用

Bilobalide is an inducer of cytochrome P450 enzymes CYP3A1 and CYP1A2. It exhibits neuroprotective, anti-inflammatory, anti-oxidative and anti-apoptotic properties. Bilobalide, a γ-aminobutyric acid (GABA) A_A-rho, 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonist, may be used to study the function of these receptors in the brain processes such as cognition and memory. It serves as a specific platelet-activating factor receptor antagonist, which helps in the treatment of cardiovascular (Alzheimer′s disease) and cerebrovascular diseases.

イチョウ(Ginkgo biloba)でみられる生理活性テルペノイド。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)