C0493

Monoclonal Anti-Calcium Sensing Receptor マウス宿主抗体

clone HL1499 (6D4-3F4-6C4), purified from hybridoma cell culture

• 別名: Anti-CAR, Anti-EIG8, Anti-FHH, Anti-FIH, Anti-GPRC2A, Anti-HHC, Anti-HHC1, Anti-HYPOC1, Anti-NSHPT, Anti-PCAR1, Anti-hCasR
• MDL番号: MFCD02262635
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA (i); ICC; IHC (p); WB
• クローン: HL1499 (6D4-3F4-6C4), monoclonal
• 化学種の反応性: rabbit, rat, mouse, human
• citations: 10
• テクニック: immunocytochemistry: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 3-6 μg/mL using total extract from rat kidney

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: HL1499 (6D4-3F4-6C4), monoclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: rabbit, rat, mouse, human
• テクニック: immunocytochemistry: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 3-6 μg/mL using total extract from rat kidney
• アイソタイプ: IgG1
• UniProtアクセッション番号: P41180
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CASR(846) ; mouse ... Casr(12374) ; rat ... Casr(24247)

詳細

詳細

The calcium sensing receptor (CASR) gene with 11 exons is mapped to human chromosome 3q13.33-q21.1. CASR is a member of the C family of G protein–coupled receptors and is mainly localized in the parathyroid gland and the thick ascending limb of the Henle loop. CASR is a 1078 amino acid protein.

免疫原

カルシウム感受性レセプタ-の細胞外N末端アミノ酸15-29に相当するペプチド。

アプリケーション

Monoclonal Anti-Calcium Sensing Receptor antibody produced in mouse is suitable for the following applications:

• Indirect ELISA
• Immunoblotting
• Immunocytochemistry
• Immunohistochemistry (formalin-fixed, paraffin-embedded sections)
• Western blotting at a concentration of 3-6μg/mL using total extract from rat kidney

Monoclonal anti-calcium sensing receptor antibody produced in mouse has been used in western blotting and immunohistochemistry.

生物化学的／生理学的作用

Calcium sensing receptor (CASR) regulates cell activity according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. Thus, this protein can be considered as a potent target for therapeutic agents designed to modify parathyroid gland function. CASR has a role in key signal transduction pathways in several tissues such as parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is associated with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

物理的形状

0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable