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About This Item
実験式（ヒル表記法）:
C22H30O4
CAS番号:
分子量:
358.47
MDL番号:
UNSPSCコード:
12352205
PubChem Substance ID:
NACRES:
NA.79
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品質水準
アッセイ
≥98%
形状
powder
テクニック
HPLC: suitable
色
white to off-white
保管温度
2-8°C
SMILES記法
CC(=O)OCC1(O)CC23CCC4c5ccoc5CCC4(C)C2CCC1C3
InChI
1S/C22H30O4/c1-14(23)26-13-22(24)12-21-9-5-17-16-7-10-25-18(16)6-8-20(17,2)19(21)4-3-15(22)11-21/h7,10,15,17,19,24H,3-6,8-9,11-13H2,1-2H3
InChI Key
PTGGVIKFNQSFBY-UHFFFAOYSA-N
アプリケーション
Cafestol acetate has been used to determine the effects of coffee on heat shock response (HSR).
生物化学的／生理学的作用
Cafestol is a coffee-specific diterpene. It has anti-carcinogenic and anti-inflammatory activities. Cafestol stimulates apoptosis in cells associated with colorectal and renal cancer (Caki cells). It is used to study mechanisms of anti-oxidation related to hydrogen peroxide induced oxidative stress and DNA damage. Cafestol increases the level of glutathione (GSH), by stimulating γ-glutamylcysteine synthetase. It acts as a chemopreventive agent by inducing cytochrome P-450.
その他情報
Furan-containing diterpene from green coffee beans.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C1305-25MG:
C1305-VAR:
C1305-BULK:
C1305-100MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Wolfgang W Huber et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(4), 1230-1238 (2007-11-07)
Coffee drinking appears to reduce cancer risk in liver and colon. Such chemoprevention may be caused by the diterpenes kahweol and cafestol (K/C) contained in unfiltered beverage. In animals, K/C treatment inhibited the mutagenicity/tumorigenicity of several carcinogens, likely explicable by
Agnieszka Potęga et al.
Journal of pharmaceutical analysis, 10(4), 376-384 (2020-09-15)
5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at all. Thus, the aim of the current
Cafestol, a diterpene molecule found in coffee, induces leukemia cell death
Lima C, et al.
Biomedicine and Pharmacotherapy, 92, 1045-1054 (2017)
Use of silver nitrate impregnated silica cartridges in the separation of kahweol and cafestol esters by preparative liquid chromatography.
L K Lam et al.
Journal of chromatography, 328, 422-424 (1985-06-28)
Kai-Shan Tao et al.
Medical hypotheses, 71(5), 730-736 (2008-08-15)
Epidemiological studies have found an inverse association between coffee consumption and the risk of liver cancer. Animal data support such a chemopreventive effect of coffee. Substantial research has been devoted to the identification of coffee components that may be responsible
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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